Sensory systems must be adaptive to allow animals to cope with changing environments. For hundreds of years, neuroscientists thought that neural plasticity came from changes in the connections…
Tag: Publication
Controlling Organellar Excess: Msp1 Eliminates Undesired Membrane Proteins from Mitochondria and Peroxisomes [Denic Lab]
The phrase “finding a needle in a haystack” refers to the difficulty of locating a specific target among a large number of very similar objects. Living cells face…
Channeling Anti-viral Immunity [Hunter Lab]
The discovery of RNA interference (RNAi) in 1998 was one of the most unexpected findings in the last 30 years. The Nobel-winning observations were made in C. elegans,…
Mother May I? Inheritance of Silencing Signals in C. elegans [Hunter Lab]
RNA interference (RNAi) is a nearly ubiquitous gene silencing phenomenon triggered by introduced double-stranded RNA (dsRNA). In some animals, including the nematode Caenorhabditis elegans, RNAi is systemic, which…
How Do Environmental Stimuli Set Individual Circadian Clocks to Stochastic Phases? [O’Shea Lab]
Many organisms on earth have evolved an endogenous self-sustained pacemaker, called the circadian clock, to anticipate daily changes in the environment and adapt its physiology. The circadian clock…
Turning the ON off: Sculpting One of Two Dendritic Branches in a Retinal Neuron [Sanes Lab]
The dendritic arbors of neurons are incredibly diverse in size and shape. This makes sense, because dendritic morphology is a critical determinant of the numbers and types of…
When Bacteria Get Stressed [Losick Lab]
All cells need to sense and respond to different stresses in their local environment in order to survive and grow, and bacteria are certainly no exception. The model…
Phosphatases and Proteases are Distant Relatives [Losick and Gaudet Labs]
Diverse cellular and developmental processes are controlled by reversible phosphorylation – the process by which phosphates are added or removed from proteins. Reversible protein phosphorylation is widely used…
Go Against the Flow [Engert Lab]
Understanding brain function generally requires a deep engagement with the matter at least at two separate levels. These are the level of behavioral algorithms on the one hand…
The First Nanoscale Rendering of an Entire Vertebrate Brain
People frequently operate computer devices such as smartphones that collect user input and process this information to produce outputs on a display or through headphones. Engineers control how…
