The genomes of most eukaryotic organisms, including humans, contain large amounts of repetitive DNA organized in the form of heterochromatin. As a result, this specialized chromatin state plays…
Tag: Publication
Do Not Go Rhythmless into That Good Night [O’Shea Lab]
The cycle of day and night is one of the most recurrent and predictable environmental change on our planet. Consequently, organisms evolved mechanisms that give them an ability…
Good Parent, Bad Parent: The Evolution of Parental Care in Monogamous Mice [Hoekstra and Dulac Labs]
Parental care is crucial for the survival of mammals, yet species vary widely in the extent and type of care they give to their young. In species where…
Who Moved My Arm? Learning from Performance Error [Uchida Lab]
You head to your favorite coffee shop, order a cappuccino, and when the barista calls your name, you grab your coffee. Imagine, however, you grab the wrong cup…
Finding Sparse Patterns in High Dimensional Single Cell Gene Expression Data [Ramanathan Lab]
During development, multipotent cells make a series of cell fate decisions, eventually leading to the various distinct cell types in the body. With the advent of high-throughput measurement…
From Motion to Mechanism: Cytoskeletal Dynamics Drive Cell Division in Bacteria [Garner Lab]
Cell division is one of the most fundamental processes of life, conserved across all kingdoms. Over the last decades, scientists have identified many of the components involved in…
Early Germ Layer Differentiation Occurs Through a Series of Discrete Cell State Transitions [Ramanathan Lab]
During mammalian development, embryonic stem cells undergo cell-fate decisions to commit to one of three germ layer lineages: ectoderm, mesoderm and endoderm. Although decades of research in developmental…
Uncovering the Dynamics of Interneuron Production and Maturation [Ramanathan Lab]
Inhibitory interneurons are a diverse population with crucial roles in cortical and striatal information processing. These cells have been implicated in human neuropsychiatric and neurodevelopmental disorders, including autism,…
The Case of the Missing Crossovers [Kleckner Lab]
Sexual reproduction involves the production of male and female gametes (e.g. sperm and egg) each of which carries a single complete set of chromosomes. In most organisms, this…
Prediction Errors Stay on Track, Even When the Ride is Unpredictable [Uchida Lab]
Imagine you are waiting for the 2PM subway train. Based on your experience, you know that the train always arrives between 1:55PM and 2:05PM. You glance at your…
