100 Years Biochemical Sciences Tutorial

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DISSECTING COMPUTATION IN THE DOPAMINE REWARD CIRCUIT

(L to R) Sebastian Haesler, Naoshige Uchida and Jeremiah Cohen In 1954, Olds and Milner discovered that direct, electrical stimulation of particular brain areas was powerfully rewarding: rats…

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KEEPING THE FAITH: THE FINAL ACT OF STOPPING CARELESS CELLS

(L-R) Derek Lau and Andrew Murray Faithful chromosome segregation during cell division keeps cells alive and keeps cancer and birth defects at bay. A chromosome’s movements during mitosis…

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RETROVIRAL RNA SNAPS INTO SHAPE!

(L-R) M. Durney, V. D'Souza, J. Nagle, Carolina Salguero Retroviruses, like all viruses, rely on host protein machinery to carry out every step in their life cycle. Therefore,…

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SMELL YOUR FRIENDS FROM YOUR ENEMIES!

Unlike humans, most animals rely heavily on scents to collect information about their external environment, and in particular assess the friendly or not-so-friendly nature of encounters with other…

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HOW TO SHUCK A SPECIALIZED CHAPERONE

(L-R) Vlad Denic, Fei Wang, Matthew Tung Eukaryotic cells target a large fraction of proteins synthesized in the cytosol to a number of different intracellular membrane compartments (organelles).…

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SCULPTING SOUND SPACE IN THE DEVELOPING BRAIN

Brain functions, such as language, are shaped by experience during windows of heightened plasticity in early life. For example, children raised in an English- speaking environment will easily…

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STICKING TOGETHER MAKES LIFE SWEETER

(L-R) John Koschwanez and Andrew Murray Many unicellular organisms secrete enzymes that release nutrients from their environment. But most of the nutrients can't be captured by the cell's…

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CISCODE, TRANS EFFECT, TRANSCRIPTION SPECIFICITY

Erin K. O'Shea and Xu Zhou Gene expression is controlled by a class of proteins called transcription factors. These proteins usually bind to short 6-8 base pair DNA…

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HOW DO PLURIPOTENT CELLS CHOOSE A FATE?

A fundamental question in developmental biology is how multi-potent cells choose a fate. While we know a lot about how cell states are maintained through growing amounts of…

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