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Tag: Publication

BACTERIAL CIRCADIAN CLOCKS TIGHTLY LINKED TO METABOLISM

Michael J. Rust and Erin K. O'Shea Circadian clocks are biological oscillators that help organisms keep track of the time of the day and coordinate their behavior with…

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HOW TO INFER CELLULAR RESPONSE TO A SMALL STIMULUS FROM BEHAVIORAL VARIABILITY BEFORE STIMULUS IN BACTERIA

Heungwon Park Over the last decade, there has been a series of remarkable studies dealing with the characterization of noise in gene regulatory networks and signaling pathways. However,…

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CHANGING THE CULTURE OF SCIENCE EDUCATION AT RESEARCH UNIVERSITIES

Rich Losick Professors at large research universities have two important responsibilities: generating new knowledge and educating students. Sometimes these missions are seen as being in competition. Indeed, we…

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RESOLVING THE MOLECULAR ARCHITECTURE OF SYNAPSES USING LIGHT MICROSCOPY

Synapses are highly specialized junctions between neurons that are the basis of our understanding of neuronal signal transmission and how memories are formed in the brain. The structure,…

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REMOVING AN ENDOGENOUS PROTOTOXIN RESTORES VISION

(L to R) Hirofumi Morishita and Takao K. Hensch Much of our behavior reflects the neural circuits sculpted by experience during early developmental critical periods. Such heightened brain…

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HOW TO FIND YOUR HOMOLOG WITHOUT LOSING YOUR SISTER

Meiosis is a modified cellular program by which a single diploid cell gives rise to haploid gametes (e.g. sperm and egg). To this end, DNA replication is followed…

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SNIFFING OUT THE ODOR CODE: A ROLE FOR SPIKE TIMING

How would you describe the smell of fresh baked bread, a rose, or an ocean breeze? The world of smell is extremely diverse, and with intangible qualities that…

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MICE THAT SMELL LIGHT

Olfaction is a critical sense for many animals, guiding their foraging behavior, mate choice and predator avoidance. Mice use ~1000 odorant receptor types in the main olfactory system…

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THE MOVING PARTS OF A TAIL-ANCHORED PROTEIN SORTING MACHINE

(L to R) Vladimir Denic and Fei Wang Membrane protein targeting is a fundamental problem in cell biology. Pioneering work by George Palade in the 1960s established that…

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